Mesopeptide

PEPTIDE MESOTHERAPY TREATMENTS IN NAPERVILLE, IL

REBUILD STRUCTURE IN THIN, AGED SKIN AND A SOFTENING JAWLINE

Rebuilding structure in thin, aged skin and a softening jawline requires a targeted approach that goes beyond standard fillers or surgery. At SMooth Solutions Medspa, our Mesopeptide treatment delivers biomimetic peptides—palmitoyl tripeptide-5 and acetyl tetrapeptide-9—combined with hyaluronic acid to rebuild density and structure for a visibly firmer result.

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WHAT IS MESOPEPTIDE?

Mesopeptide is a peptide mesotherapy booster built to rebuild structure rather than simply hydrate. Designed to address:

  • Softening Jawline: Loss of definition along the jaw without wanting filler or surgery.
  • Thin, Aging Skin: Skin that’s lost density and structural support.
  • Sagging: General loss of firmness across the face.
  • Non-Surgical Preference: Wanting a structural approach that isn’t an injectable filler.

Combining biomimetic peptides—palmitoyl tripeptide-5 and acetyl tetrapeptide-9—with hyaluronic acid, this treatment works to rebuild density and structure in thin, aged skin and a softening jawline for a visibly firmer result without surgery or filler.

It is delivered during an RF microneedling, microneedling, LaseMD Ultra, or PRÉIME DermaFacial appointment, allowing the peptides to reach the deeper layers of skin where that structural support actually needs to be rebuilt.

Mesopeptide

YOUR MESOPEPTIDE TREATMENTS IN NAPERVILLE

Treatment information

Key Actives

  • Palmitoyl tripeptide-5
  • Acetyl tetrapeptide-9
  • Hyaluronic acid

Best For

  • Sagging
  • Loss of jawline definition
  • Thinning skin

Pairs With

  • RF Microneedling
  • Microneedling
  • LaseMD Ultra
  • PRÉIME DermaFacial

Downtime

No downtime beyond your paired treatment

Consultation

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Your provider assesses your skin’s density, firmness, and jawline definition to confirm your candidacy for the Mesopeptide treatment.

Once your treatment plan is confirmed, we guide you through the recommended procedures, expected results, and any preparation required so you feel fully confident.

Treatment

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Mesopeptide is added to your RF microneedling, microneedling, or laser appointment, delivering biomimetic peptides and hyaluronic acid to the deeper skin layers.

Firmness builds gradually over a course of sessions as the peptides actively support and rebuild the skin’s structure without surgery or filler.

Post-Treatment

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There is no downtime beyond your paired treatment, though you may experience normal mild recovery effects depending on the primary procedure.

Firmness and structural definition build progressively over a course of sessions, helping you achieve long-term, visibly firmer results along a softening jawline.

YOUR PERSONALIZED MESOPEPTIDE RESULTS

Our peptide mesotherapy treatments follow a structured, medical-grade approach to rebuilding skin density and structural support. By targeting concerns at a deeper layer, results develop progressively and are tailored to your skin type, age, and goals.

JAWLINE REDEFINITION

Targeted peptide mesotherapy helps redefine a softening jawline and restore structural contours without the need for surgery or filler.

STRUCTURE AND DENSITY RESTORATION

Biomimetic peptides—palmitoyl tripeptide-5 and acetyl tetrapeptide-9—combine with hyaluronic acid to rebuild density and support in thin, aged skin.

IMPROVED SKIN FIRMNESS AND TIGHTENING

Delivered during RF microneedling, microneedling, LaseMD Ultra, or PRÉIME DermaFacial appointments, the treatment improves skin elasticity and firmness, reducing sagging and creating a visibly firmer result over time.

PROGRESSIVE REJUVENATION

As treatments continue, firmness builds gradually over a course of sessions as the peptides support the skin’s structure.

BRIGHTER, HEALTHIER-LOOKING SKIN

With no downtime beyond your paired treatment, your complexion benefits from enhanced structural support and cellular renewal.

LONG-TERM MAINTENANCE AND PREVENTION

Maintaining your results requires consistency. With a personalized maintenance plan and proper skincare, you can preserve your structural improvements and continue supporting skin health over time.

SCHEDULE YOUR MESOPEPTIDE APPOINTMENT IN NAPERVILLE

1867 Bay Scott Circle Suite 111 Naperville IL 60540
(630) 381-8952

CONTINUED IMPROVEMENT WITH MESOPEPTIDE TREATMENTS

  • Progressive Rejuvenation: Biomimetic peptides and hyaluronic acid support the skin’s structure, helping firmness build gradually over a course of sessions.
  • Improved Skin Quality: As treatments continue, thin and aging skin becomes smoother, firmer, and more resilient.
  • Brighter, Clearer Complexion: Enhanced structural support and cellular renewal reveal a more radiant, youthful appearance.
  • Smoother Texture: Targeted peptide mesotherapy refines texture and improves overall skin feel along a softening jawline.
  • Long-Term Maintenance Control: With proper skincare, sun protection, and a personalized maintenance plan, structural results can be preserved over time.

Significant improvements can be seen in skin density, structural support, and firmness, leading to a visibly firmer and more defined appearance.

Mesopeptide works where the skin needs structural rebuilding, delivered during RF microneedling, microneedling, LaseMD Ultra, or PRÉIME DermaFacial appointments. Rather than adding volume like a dermal filler, this booster targets the deeper layers to rebuild density and support.

As your treatment plan progresses, you will notice gradual yet consistent improvements. With ongoing care and maintenance, results continue to build, helping you achieve a firmer, more redefined, and youthful-looking complexion.

OUR DIFFERENCE? MEDICAL PRECISION, STRUCTURED PROTOCOL, EVIDENCE-BASED PEPTIDE MESOTHERAPY

At SMooth Solutions Medspa, we focus on a science-driven approach to rebuilding skin density and structural support. Every treatment plan is built on clinical understanding, allowing you to make informed decisions about your skin and results.

While many treatments focus only on surface-level improvements, our approach delivers biomimetic peptides—palmitoyl tripeptide-5 and acetyl tetrapeptide-9—combined with hyaluronic acid to rebuild density and structure in thin, aged skin and a softening jawline. This ensures more effective, balanced, and structurally supported outcomes.

Through expert assessment, customized treatment planning, and structured follow-up care, we help you achieve visible improvements that continue over time. Our goal is not just short-term rejuvenation but long-term skin health, confidence, and natural structural support.

 

About

Mesopeptide treatments can help improve multiple concerns including skin sagging, loss of jawline definition, and thinning skin.

Frequently Asked Questions

Can Mesopeptide replace filler?

How is this different from Mesotox?

How many sessions will I need?

Does this add downtime?

What should I pair it with?

Testimonials

I had struggled with thinning hair for a long time, and nothing I tried made a real difference. After starting PRP hair restoration at Smooth Solutions MedSpa, I finally saw improvement. My shedding reduced, my hair started feeling thicker, and the overall health of my scalp improved. The team explained everything clearly and made the entire process comfortable from start to finish. I will definitely continue my maintenance sessions here.

I highly recommend this spa. It is more like a medical office without all the spa/salon nonsense. They specialize in hair removal and skin treatments. I had laser hair removal and a photo facial (BBL). Both procedures way exceeded my expectations. I would not go anywhere else. The equipment is top notch and the staff is very knowledgeable. Everything was explained to me so I knew what to expect. Prices are very reasonable. If I had known what results can be achieved with a 30 minute photo facial, I would have gone sooner. Ditch the expensive face creams and salon facials and get a photo facial (BBL). I look years younger after one treatment!

Staff are very well trained and highly informative. Staff was caring and professional. I would refer clients who are looking for highly effective treatments with the most advanced equipment utilized by knowledgeable and empathic staff in a friendly and personal yet professional environment.

I have had the absolute best experience with Smooth Solutions Medspa and I highly, highly recommend their services. Mariam clearly enjoys her business and takes the time to educate her clients on the equipment that she has chosen to use and the best services for one's desired results. I have been, quite frankly, amazed at my results. Do yourself a favor and call Smooth Solutions before you commit to laser hair removal or electrolysis anywhere else.

I cannot recommend Mariam and this place highly enough! From the moment I stepped into her studio, I was greeted with warmth and professionalism by a very sweet front desk assistant.

My recent BBL session with Mariam was an absolute game-changer. Not only did she thoroughly explain the procedure beforehand, but she also took the time to understand my skincare concerns and goals. Her knowledge instantly put me at ease. She took the time to follow up with me after the session to ensure I was happy with the results and offered valuable skincare tips for the future. Her expertise and attention to detail truly set her apart.

I have been a longtime waxer and finally got tired of the inconsistency. I’ve been going here for Laser Hair Removal and it has been the best decision I could have made. They are all so efficient, friendly, and very knowledgeable. At my consultation everything was explained to me, and even during my appointments I was given more knowledge in regards to the hair and skin. I HIGHLY recommend SMooth Solutions to everybody!! It is one of the best investments you can make on yourself!!

 

The results are AMAZING! I have tried various laser hair removal places throughout the years and this by far has given me the best results. Miriam is very welcoming, patient, and makes you feel very comfortable. I highly recommend this place!

 

I'm very happy that I found this place, they are very professional and always do their best to help each client according to their needs. I definitely recommend any of the services that they provide. I had the Halo treatment and I can see the improvement in my skin. Mariam is professional and very pleasant to work with.

Beth is so warm and professional. She makes me feel so comfortable and that allows me to relax for my appointment. She really goes above and beyond and is so gifted at what she does!:) 10/10 recommend this business!

 

After one laser appointment which was over 2 months ago I haven’t had any hair growth. Great facility, great owner, and most of all, tremendous results!!

Amazing results after 2 sessions! Always kind and understanding and makes you feel very comfortable! Very happy with this service! Thank you

So, there are so many things I love about Smooth Solutions I don't know where to start! Firstly, the staff is amazing. They're attentive, timely, professional and skilled. Laser - I have dense, thick hair pretty much everywhere. After ONE treatment on my legs with their laser I haven't seen any growth in almost 8 weeks. Amazing. Electrolysis- Mariam cares and takes pride in her results. I have already seen incredible improvement over the course of about 6 sessions. If you're debating where to go for hair removal, Smooth Solutions is the place!

I have been here for two times and I have noticed a difference, the laser technology they use is amazing and has improved the overall look of my skin. I’m very excited to see the final results after finishing my treatment.

Mariam is amazing! She is very well informed with what she does and shares that information to her clients. She is upfront with cost and has great quality of work. She checks in with her clients and supports them throughout their treatments. She is great at working with clients with PCOS, like myself. She personalizes each treatment to fit your need. You can see that she loves what she does and is the best option for hair removal.

I did a Halo treatment with Miriam. I love my results. I can really see the difference in my face and skin. Definitely go with Miriam she's a sweet heart and she makes sure to answer all of your questions.

I began electrolysis and laser treatments on lip, chin, and neck in December after several years of tweezing, waxing, threading, and shaving. My facial hairs had become very corse and thick. I noticed a difference after only 2 treatments. Now in April, I see a big difference. The staff at Smooth Solutions has been friendly, knowledgeable, and accommodating with appointments. I was very uncomfortable and ashamed going in the first time, but before the first appointment was complete, those feelings were gone. The staff explains things in a way you can easily understand and puts your mind at ease. I was surprised to find facial hair in women is not uncommon and that something can be done about it!

Kayci was super friendly, helpful, and knowledgeable, and made my laser treatment an absolute breeze! Looking forward to coming back next month!

I decided I wanted to try a photofacial aka Forever Young BBL, to help my skin with discoloration, broken capillaries and redness. I have rosacea and I felt like I needed to take steps to correct and prevent. Miriam has been great! She is very knowledgeable and passionate about her work. She really makes you feel at ease about everything and answered every question I could come up with. After I was done I noticed some improvements right away. Lots of the broken capillaries were gone. The redness was gone. I had a cherry angioma on my forehead that is completely gone! My skin texture was refreshed looking, smoother and more youthful. There is literally no downtime. There is no peeling or anything that would prevent you from going about your regular day. After a week, my skin looked smoother, my pores seemed smaller. After two weeks it feels like I hardly need any foundation. I can just use some concealor and go! I saw my daughter a couple weeks after and the first thing she said was that my skin looked great. She didn't even know I had the laser done. This is something that I will continue to get done. The results are so great, I just wish I would have started doing this sooner!

I came here for my first experience of laser hair removal and I will not be going anywhere else! After my first treatment, I noticed results. I didn’t expect to see results so soon, but I did! Thank you so much for my experience and for making me feel so comfortable!

I struggled with uneven texture, acne scarring, and dull skin for years, and nothing I tried made a real difference. After starting PRP microneedling at Smooth Solutions MedSpa, I finally saw visible improvement. My skin looked smoother, my pores appeared smaller, and my overall tone became brighter and more even.
The team explained every step clearly and made the entire experience comfortable from start to finish. I’m so happy with my results and will definitely continue my maintenance sessions here.

I struggled with dark circles and fine lines under my eyes for years, and nothing seemed to help. After starting PRP under-eye treatments at Smooth Solutions MedSpa, I finally noticed real improvement.
My under-eye area looked brighter, the crepiness softened, and my skin felt healthier and more refreshed.
The team explained every step clearly and made the process comfortable from beginning to end.
I’m so happy with my results and will definitely return for maintenance sessions.

I wanted something natural to refresh my under-eyes without looking like I had filler, and PRF EZ Gel was the perfect fit. The results came in gradually but made such a difference. My skin looks smoother, brighter, and just healthier overall. I feel like myself — just more rested.

“This was my first experience with Botox, and I was honestly nervous about looking frozen. The team at SMooth Solutions made the whole process feel comfortable and professional from start to finish. Two weeks later, my frown lines were noticeably softer, and the results looked natural enough that even my friends couldn’t tell I had anything done.” — Lauren T., Aurora

“I wanted softer lines without looking overdone, and that’s exactly what I got. The injector took time to explain the difference between Botox & Dysport and created a plan that fit my face instead of using a one-size-fits-all approach. My forehead looks smoother, but I still look completely like myself.” — Jessica M., Naperville

“I noticed a real difference in my skin texture within a couple of weeks. It feels smoother, looks brighter, and even my fine lines have softened. The whole process was comfortable, and the team made me feel completely at ease. I would definitely recommend exosome therapy to anyone looking for natural skin rejuvenation.”

“I combined exosome therapy with microneedling, and the results were incredible. My skin healed faster, and the glow I got afterward was amazing. It didn’t feel like a harsh treatment at all. This has become part of my regular skincare routine now.”

“I’ve had Botox before at other places, but this experience felt much more personalized. They really studied how my face moves and explained every injection point before starting. My crow’s feet and forehead lines are softer, but my expressions still feel natural. It’s the refreshed look I was hoping for.” — Emily R., Plainfield

“I was looking for something effective but gentle, and this treatment was exactly that. My skin looks firmer, more even, and refreshed without any downtime. It’s perfect for busy schedules, and the results feel very natural.”

“I wanted something non-invasive to help with redness and dull skin, and this treatment was perfect. After a few sessions, my skin looked calmer, clearer, and more radiant. It’s relaxing, quick, and fits easily into my routine.”

“I did Healite LED after another skin treatment, and the recovery was so much faster than I expected. The redness reduced quickly, and my skin felt healthier overall. It’s now something I always include in my treatments.”

“I struggled with breakouts and uneven skin tone, and this made a noticeable difference. My skin looks clearer, smoother, and has a healthy glow without any irritation. It’s one of the easiest treatments I’ve tried with great results.”

“I was honestly surprised how quickly I saw results. Within a week, my skin looked brighter, smoother, and more even. The peeling process was manageable, and the results were absolutely worth it. I feel so much more confident without makeup.”

“I struggled with acne scars and uneven tone, and this treatment made a noticeable difference. My breakouts reduced, and the dark spots started fading after just one session. It’s one of the best treatments I’ve tried so far.”

“I wanted something effective but not too aggressive, and the VI Peel was perfect. My skin feels refreshed, smoother, and has a healthy glow. The team explained everything clearly, and the whole experience was very comfortable.”

“After a few sessions of Laser Genesis, I noticed my pores looked smaller and my skin felt much smoother. It’s a gentle treatment, but the results really build over time. My complexion looks more even and refreshed.”

I struggled with my weight for years, but this program finally changed everything for me. Within the first month on Semaglutide, my cravings dropped, my portion sizes naturally got smaller, and I felt in control for the first time in a long time. The team monitored me closely, adjusted my dose when needed, and made the whole experience simple and supportive. I’ve lost 22 pounds so far, and it feels sustainable — not forced. I finally feel like myself again.

“I’ve always struggled with redness, and this treatment helped calm my skin without irritation. It’s warm and relaxing, and there’s no downtime at all. My skin tone looks much more balanced now.”

“I love how easy this treatment is. I can go right back to my day, and my skin just keeps improving with each session. It looks brighter, healthier, and more youthful without anything harsh.”

“I appreciated how tailored everything was to my body and goals. It didn’t feel like a one-size-fits-all plan. I’ve seen real progress, and my energy levels have improved too. It’s been a life-changing experience.”

“What I liked most was that this wasn’t a quick fix. The team helped me build habits I can actually maintain. The medication support made the process easier, and the results have been consistent and realistic.”

“I’ve tried so many diets before, but nothing worked long term. This program gave me real structure and medical support. I’ve lost weight steadily, and more importantly, I feel healthier and more confident than ever.”

“The esthetician really took the time to understand my skin concerns and explained everything clearly. The whole experience was relaxing and professional. My skin looked smoother and more refreshed after just one visit.”

“I’ve tried so many facials before, but this was completely different. The treatment was customized to my skin, and I could see the difference right away. My skin feels balanced, hydrated, and much healthier overall.”

“I love how my skin looks after every session. It’s not just a temporary glow, it actually improves over time. My texture has improved, my pores look smaller, and I feel more confident without makeup.”

“I love how my face looks more defined now. The cheek filler added structure and contour while still keeping everything soft and natural. The process was quick, and the results are exactly what I hoped for.”

“I had volume loss in my midface, and this treatment brought back a youthful look without being obvious. The results are smooth and balanced. Friends noticed I looked better, but couldn’t tell what I had done.”

“I wanted a natural enhancement, and that’s exactly what I got. My cheeks look fuller and lifted, but nothing looks overdone. It refreshed my whole face, and I feel more confident every day.”

“I love how my skin feels firmer and smoother after the treatment. It’s not just about fat reduction, it really improved the overall look of my body. I feel more confident in everything I wear now.”

“No matter how much I worked out, certain areas just wouldn’t change. After a few sessions, I finally saw real improvement. My body looks more defined, and the results feel natural, not drastic.”

“I was looking for a non-surgical way to shape my body, and this treatment delivered exactly that. I’ve seen a visible reduction in stubborn areas, and my clothes fit so much better now. The process was easy and comfortable.”

“These treatments gave me back my confidence. My skin feels tighter, brighter, and healthier. I love that the approach is personalized and focused on long-term results, not just a quick fix.”

“I wanted to look more refreshed without going through anything invasive. The results are subtle but powerful. My skin tone is more even, and I look more energized overall.”

“I started noticing fine lines and dullness, and these treatments made such a difference. My skin looks smoother, firmer, and much more youthful. It’s a natural improvement, not overdone at all.”

“I’ve tried multiple services here, and every experience has been excellent. The staff is knowledgeable, the environment is welcoming, and my skin keeps improving over time. I wouldn’t go anywhere else.”

“I was worried about looking overdone, but the results are very natural and balanced. The clinic focuses on enhancing your features, not changing them. I look refreshed and more confident without it being obvious.”

“From the consultation to the treatment, everything felt very professional and well explained. The team really listens and creates a plan that suits your skin. I’ve seen consistent improvement, and I trust them completely with my treatments.”

“I came in with uneven skin tone and rough texture, and the results have been impressive. My skin feels refined, and the overall look is much more even. The team explained everything clearly and made the experience comfortable.”

“I came in with uneven skin tone and rough texture, and the results have been impressive. My skin feels refined, and the overall look is much more even. The team explained everything clearly and made the experience comfortable.”

“I loved how the treatment was designed specifically for my skin concerns. It didn’t feel like a standard procedure. My skin looks clearer, smoother, and more balanced after just a few sessions.”

“The injector was extremely skilled and took time to understand what I wanted. The results are smooth, balanced, and exactly what I hoped for. I feel more confident every time I look in the mirror.”

“I didn’t want anything obvious, just a more rested look. The treatment gave me exactly that. My lines are softer, and I look more youthful without anyone noticing I had something done.”

“I was nervous about injectables, but the results are so natural. My face looks refreshed and more balanced, not overdone at all. The team really focuses on enhancing your natural beauty.”

“The whole session was so relaxing, but what impressed me most were the results. My skin looks smoother, brighter, and more even. It’s now part of my regular skincare routine.”

“The esthetician took time to understand my skin and recommended the right treatment. It wasn’t a generic facial. My skin texture improved, and I noticed fewer breakouts within a week.”

“I’ve had facials before, but this was on another level. My skin felt deeply cleansed and hydrated right after the session. The glow lasted for days, and my complexion looks healthier overall.”

If you are looking for a professional office with custom attention, this is it! The medical background teamed with the personal suggestions make this office the best fit for my needs. I have done laser hair removal, BBL, Halo and even electrolysis. I will continue to visit this office for future services like facials and additional BBL treatments.

I’ve been searching for good skin care for so long, and was beyond thrilled to find this place! They’re extremely educated and sincerely passionate about what it is that they have to offer! Cannot speak highly enough! Beyond thrilled!

I’ve been to a number of different places for face treatments in California and really liked Fractional CO2 laser resurfacing I received with my dermatologist many years ago. I went in for a consultation at SMooth Solutions Medspa and met with the owner. I was very quickly impressed by her knowledge, not only of the treatments, but the underlying mechanics of the machines. We spoke about what I was looking for and she provided a treatment unique to my needs. I am about 1 week post-treatment and I can already see some improvements. To be fair tho, this stuff really takes multiple months to really see the benefits, but it is already noticeably better than when I had treatments at LaserAway.

Mesopeptide

Combinable Treatments

Mesopeptide treatments can be combined with other advanced procedures to enhance results, improve skin density, and support long-term rejuvenation. Treatments such as RF microneedling, microneedling, LaseMD Ultra, and PRÉIME DermaFacial work together to allow the biomimetic peptides and hyaluronic acid to reach the deeper layers of skin where structural support needs to be rebuilt. When combined strategically, these treatments can enhance absorption of active ingredients, accelerate skin renewal, and deliver more noticeable and longer-lasting results. A customized combination approach allows us to target multiple concerns at once, including sagging, loss of jawline definition, and thinning skin.

 

Our personalized treatment plans may also include bundled options designed to maximize value and results. During your consultation, we will recommend the best combination based on your skin type, concerns, and long-term goals.

 

LEARN MORE

Mesopeptide

GET YOUR MESOPEPTIDE TREATMENT NOW

Restore a smoother, firmer, and more structured appearance with our advanced peptide mesotherapy treatments. From delivering biomimetic peptides—palmitoyl tripeptide-5 and acetyl tetrapeptide-9—combined with hyaluronic acid directly into the deeper skin layers to rebuild density in thin, aged skin and a softening jawline, we create personalized plans to target your unique concerns and deliver natural-looking results.

Visit our clinic for a professional skin evaluation or choose a virtual consultation to get started from the comfort of your home.

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Prioritize your self-care and unlock year-round benefits with the SMooth Solutions Membership Program. This exclusive opportunity allows you to enjoy substantial savings on skin care and explore the best products, treatments and services we have to offer at one convenient monthly cost. We provide flexible membership programs for anti-aging treatments and laser hair removal, so you can pick the package that meets your needs. Sign up today to get started!

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